Despite the massive amounts of popularity and success Radiohead has experienced in the last 10-15 years, perhaps their most widely known and famous song is "Creep" off their 1993 debut Pablo Honey. The beauty of creep is how thinly veiled it is. More than most any other song it is straight forward, to the point, and honest. In my opinion, the reason why it's so popular is because at some point everyone has longed to be included, but felt so hopelessly different than everyone else.
Take a listen to Sarah Jaffe covering Radiohead's "Creep". What's most powerful about the performance is the sold out crowd singing along to every word. It's truly beautiful.